Statins as immunosuppressive agents

Medicinal Plants as Immunosuppressive Agents in Traditional Iranian Medicine

Statins as immunomodulatory agents.

Statins have long been thought to exert their benefits by reducing cholesterol synthesis. However, the fact that mevalonate is the precursor of isoprenoids that regulate diverse cellular functions has led investigators to examine pleiotropic effects for these agents. Major histocompatibility complex class II (MHC-II) molecules, which affect the immune response and organ rejection after transpla...

The statins as anticancer agents.

1,072,503 person-year of follow-up, 195,594 patients died: 162,067 from cancer, 14,489 from cardiovascular causes and 19,038 from other causes. Among patients, 40 years and older, 18,721 received statins before cancer diagnosis and 277. 204 had never used statins. All cause mortality among patients with cancer taking statins was reduced by 15%, and only by 10% as risk for death from cardiovascu...

The statins as anticancer agents.

3-Hydroxy-3-methylgutaryl CoA reductase inhibitors, commonly referred to as the statins, have proven therapeutic and preventative effects in cardiovascular diseases. Recently, there are emerging interests in their use as anticancer agents based on preclinical evidence of their antiproliferative, proapoptotic, anti-invasive, and radiosensitizing properties. Inhibition of 3-hydroxy-3-methylgutary...

Traditional Chinese medicines as immunosuppressive agents.

INTRODUCTION Traditional Chinese Medicines (TCM) have been used for centuries in China to treat various immune-mediated disorders. METHODS This review focuses on the clinical and experimental studies that have been performed with TCM as immunosuppressive agents for the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), atopic eczema and solid organ transplantation. ...